Why does someone calmly drink several cups of coffee a day, while others, after just one small cup, have blood pressure rise and tachycardia begin?
“The main enzyme responsible for the metabolism of caffeine in our body is the enzyme cytochrome P450 1 A2 and, consequently, its gene CYP1A2. If the cytochrome is normal and active, you can drink the same recommended number of cups of coffee per day . day,” Irina Kolesnikova, candidate of Biological Sciences and senior researcher at the National Center for Genetic Research (MyGenetics), explained to Rossiyskaya Gazeta.
Interestingly, a cup of coffee a day is even beneficial for these people; For example, it reduces the risk of myocardial infarction. Perhaps this is due to the fact that this very cup of coffee “stimulates” the work of cytochrome and gets to work with even greater zeal. So, for those with a normal, “good” genotype, this is great news: a cup of coffee is good for you.
But genetic variants are known in which the function of the enzyme is affected and the metabolism of caffeine is slowed down. So you shouldn’t drink coffee in large quantities.
“Especially if both genetic variants are unfavorable. In this case, it is generally better to replace coffee with other beverages. When drinking large amounts of coffee (4 cups a day or more), the risk of myocardial infarction in these people increases. quadruples. And, by the way, “this situation is observed on average in one in 8-9 people. Also, remember that caffeine, in addition to your favorite drink, is also found in some popular medications, such as citramon and Askofen,” the specialist warned.